Monocyte Chemoattractant Protein-1 Deficiency is Protective in a Murine Stroke Model

Psgl-1 Deficiency is Protective against Stroke in a Murine Model of Lupus

Systemic lupus erythematosus (SLE) is associated with an elevated risk of vascular complications, including premature stroke. Therapies targeting leukocyte recruitment may be beneficial in reducing vascular complications associated with SLE. Lupus was induced in female wild-type (WT) and P-selectin glycoprotein ligand-1 deficient (Psgl-1(-/-)) mice with pristane. Stroke was induced following ph...

Monocyte chemoattractant protein-1-deficiency results in altered blood-brain barrier breakdown after experimental stroke.

BACKGROUND AND PURPOSE Stroke-induced blood-brain barrier (BBB)-disruption can contribute to further progression of cerebral damage. There is rising evidence for a strong involvement of chemokines in postischemic BBB-breakdown. In a previous study, we showed that monocyte chemoattractant protein-1 (MCP-1)-deficiency results in a markedly reduced inflammatory reaction with decreased levels of in...

Urine Monocyte Chemoattractant Protein-1(UMCP-1) as a Biomarker of Renal Involvement in Systemic Lupus Erythematosus

Objective(s)Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of LN. The study,s purpose was to evaluate the performance of urinary monocyte chemoattractant protein 1(UMCP-1) as a biomarker of renal involvement in systemic lupus erythematosus.Mate...

Murine Lung Fibroblasts Modulates CD4 Monocyte Chemoattractant Protein-1 Synthesis

Monocyte Chemoattractant Protein-1 Synthesis